|
|||
 |
|||
|
Valsartan - Doivan reduces blood pressure across its dose range, though an 80 mg dose achieves near maximal blood pressure reduction. Increasing the valsartan dose from 160 mg to 320 mg provides marginal additional blood pressure reduction. This is unlikely to be clinically meaningful and increasing the dose increases the risk of adverse reactions. The recommended starting dose of Diovan is 80 mg once daily when used as monotherapy in patients who are not volume-depleted. Diovan may be used over a dose range of 80 mg to 320 mg daily, administered once-a-day. The antihypertensive effect is substantially present within 2 weeks and maximal reduction is generally attained after 4 weeks. If additional antihypertensive effect is required, the dosage may be increased to 160 mg or 320 mg or a diuretic may be added. Addition of a diuretic has a greater effect than dose increases beyond 80 mg. No initial dosage adjustment is required for elderly patients, for patients with mild or moderate renal impairment, or for patients with mild or moderate liver insufficiency. Care should be exercised with dosing of Diovan in patients with hepatic or severe renal impairment. Diovan may be administered with other antihypertensive agents. |
|||
|
|||
|
|||
|
|||
|
