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Bupropion or Zyban is use to reduce withdrawal symptoms experienced in smoking cessation. Zyban acts at the nervous system level to counteract the symptoms of withdrawal - irritability, dizziness. It also seems to reduce the urge to smoke. Zyban can potentially interact with a number of other medicines. In combination with other drugs that affect the nervous system, Zyban can enhance nervous system effects. For smoking cessation, Zyban can be used with nicotine replacement therapy - this will increase the success rate. Other Antidepressants - Taking Zyban with other antidepressants may affect the levels of the medications in your blood, potentially increasing your risk of side effects. Also, taking Zyban with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining Zyban with other antidepressant medications. Amantadine - Taking Zyban and amantadine together may increase your risk of side effects. To prevent this, your healthcare provider may decide to start you at a lower Zyban dose if you are taking amantadine. Antipsychotic Medications - Zyban can raise the levels of some antipsychotic medications in your blood, which may increase your risk of side effects. Also, taking Zyban with antipsychotic medications may increase your chances of seizures. Talk with your healthcare provider before taking these medications together. Beta Blockers - Zyban may raise the levels of beta blockers in your blood, potentially increasing your risk of side effects. Depending on your particular situation, if you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to decrease your beta blocker dose. Certain Arrhythmia Medications - Zyban can increase the levels of certain arrhythmia medications in your blood, possibly increasing your risk of side effects. To prevent this, your healthcare provider may need to monitor you more closely, especially when you are starting or stopping Zyban. Monoamine Oxidase Inhibitors (MAOIs) - You should not take Zyban if you have taken an MAOI within the past 14 days, due to the increased risk of dangerous side effects. Levodopa: Combining Zyban and levodopa may increase your risk of side effects. To prevent this, your healthcare provider may decide to start you at a lower Zyban dosage if you are taking levodopa. |
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