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For people taking Plavix (clopidogrel), dosage guidelines usually recommend taking one Plavix 75 mg tablet each day. To maintain an even level of the medication in the blood, Plavix should be taken at the same time each day. While the Plavix dosage can be taken with or without food, it's important not to break, chew, or crush the tablets. A new study reveals doubling the current recommended dose of Plavix (clopidogrel) to angioplasty patients, from 300 milligrams to 600, cut the combined risk of heart attack and cardiac death by half. The incidence of cardiac death or non-fatal heart attack was 50 percent lower in the following 30 days in those getting the higher dose of Plavix. Only 3.1 percent of those getting the 600 milligram dose had in-hospital heart attacks, compared to 6.4 percent of those getting the 300 milligram dose. The overall 30-day incidence of death or heart attack was 3.8 percent for the higher dose and 7.3 percent for the lower dose, according to the study. Timing also plays a role in treatment. Plavix must be activated in the liver, which takes about six hours, so giving it earlier makes it more effective. |
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