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Halotestin (Fluoxymesterone) is used in hormone therapy to treat breast cancer. It is a palliative treatment for recurrent estrogen-receptor positive breast cancer. Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapy can work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. The different types of hormone therapies are categorized by their function and/or the type of hormone that is effected. Halotestin is classified as an androgen. Androgens are hormones found in both men and women, but they are commonly referred to as male sex hormones. They promote the development and maintenance of male characteristics. In women, these hormones can be converted into estrogen. Androgens as cancer therapy are used to oppose the activity of estrogen. Androgen administration redirects the synthesis of estrogens that occurs in the adrenal glands. This indirectly results in a lowering of the estrogen level in the blood, thereby slowing the growth of cancer. |
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