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Salbutamol (Albuterol) adverse reactions and percent incidence

In clinical trials, the most frequent adverse reactions to Albuterol tablets were:

  • Nervousness 20%
  • Tremor 20%
  • Headache 7%
  • Tachycardia 5%
  • Palpitations 5%
  • Muscle cramps 3%
  • Nausea 2%
  • Sleeplessness 2%
  • Weakness 2%
  • Dizziness 2%
  • Drowsiness less than 1%
  • Restlessness less than 1%
  • Irritability less than 1%
  • Chest discomfort less than 1%
  • Flushing less than 1%
  • Difficulty in micturition less than 1%

Rare cases of urticaria, angioedema, rash, bronchospasm, and oropharyngeal edema have been reported after the use of Albuterol.

In addition, Albuterol, like other sympathomimetic agents, can cause adverse reactions such as hypertension, angina, vomiting, vertigo, central nervous system stimulation, unusual taste, and drying or irritation of the oropharynx.

The reactions are generally transient in nature, and it is usually not necessary to discontinue treatment with Albuterol tablets. In selected cases, however, dosage may be reduced temporarily; after the reaction has subsided, dosage should be increased in small increments to the optimal dosage.
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