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The active ingredients of the Essentiale Forte preparation are essential phosppholipides. In normal conditions the body synthesizes all the needed for the liver phospholipides and in cases of liver impairment the function of the liver can be improved by adding to the diet such substances. The deficiency of phospholipides leads to impairment of liver cell wall function. The deficiency of phospholipides also leads to impairment of fat metabolism and thus hepatic steatosis. Essenciale works by improving the above mentioned effects, promotes cell membrane regeneration, reactivates different enzyme systems and receptors, increases the detoxification ability of the liver and through that mechanism normalizes liver function. Normalization of heart muscle phospholipid metabolism and reactivation of the activity of membrane-bound enzymes participating in the reactions of biosynthesis of nucleic acids have been studied. These investigations were carried out under the conditions of experimental myocardial infarction. The effects of essential forte have been examined when it was combined with both a tocopherol, and sodium nucleinate. It was pointed out that essential forte using without other reagents leads to the depression of nucleic acids biosynthesis in affected heart muscle, while the combinations of it with a-tocopherol, and especially with sodium nucleinate are accompanied by the significant intensification of reactions of formation of desoxynucleic and ribonucleic acids biosynthesis in necrotic areas as well as in peripheral regions of affected myocardial tissue. These positive changes are accompanied also by the pronounced normalization of haemodynamic activity of infarcted myocardium. |
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