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Caverject (alprostadil) is administered by direct intracavernous injection. A half inch, 27 to 30 gauge needle is generally recommended. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician.
Caverject treatment dosages:
Erectile dysfunction of vasculogenic, psychogenic or mixed aetiology:
The initial dose of alprostadil is 2,5 micrograms. The second dose should be 5 micrograms if there is a partial response, and 7,5 micrograms if there is no response. Subsequent incremental increases of 5-10 micrograms should be given until an optimal dose is achieved. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. The patient must stay in the physician’s office until complete detumescence occurs. If there is a response, then there should be at least a 1-day interval before the next dose is given.
Erectile dysfunction of pure neurogenic (spinal cord injury) aetiology:
Dose titration should be initiated at 1,25 micrograms. The dose may be increased by 1,25 micrograms to a dose of 2,5 micrograms, followed by an increment of 2,5 micrograms to a dose of 5 micrograms, and then in 5 microgram increments until the dose that produces an erection suitable for intercourse and not exceeding a duration of 60 minutes. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. If there is a response, then there should be at least a 1-day interval before the next dose is given.
The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly.
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