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Arimidex (anastrozole) dosage and administration

Arimidex is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer, for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer and for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

The dose of Arimidex is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Arimidex should be continued until tumor progression.

Patients with Hepatic Impairment:
Hepatic metabolism accounts for approximately 85% of anastrozole elimination. Although clearance of anastrozole was decreased in patients with cirrhosis due to alcohol abuse, plasma anastrozole concentrations stayed in the usual range seen in patients without liver disease. Therefore, no changes in dose are recommended for patients with mild-to-moderate hepatic impairment, although patients should be monitored for side effects. Arimidex has not been studied in patients with severe hepatic impairment.

Patients with Renal Impairment:
No changes in dose are necessary for patients with renal impairment.

Use in the Elderly:
No dosage adjustment is necessary.
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