Androstenedione: What It Is, How It Works, and What to Watch For

If you’ve ever skimmed a fitness forum or heard friends talk about “A4,” they’re probably referring to androstenedione. In plain terms, it’s a steroid hormone that sits right before testosterone in the body’s production line. Because of that spot, many people think taking it will raise their testosterone levels and boost muscle growth.

How Androstenedione Affects Your Body

When you swallow an androstenedione supplement, your liver converts part of it into testosterone and estrogen. That means you might notice a slight increase in strength or libido, but the effect isn’t huge for everyone. Your genetics, diet, and training routine play bigger roles than any single pill.

The hormone also shows up naturally in small amounts in men, women, and even kids. In adults, it helps balance other hormones. That’s why doctors once used it to treat low testosterone, although newer drugs have taken its place because they’re safer and more predictable.

Typical Dosage and Safety Tips

Most over‑the‑counter brands suggest 300–500 mg per day, split into two doses. Beginners usually start at the low end to see how their body reacts. Keep an eye on any mood swings, acne, or changes in menstrual cycles—those can be signs of too much estrogen conversion.

Because it’s a hormone precursor, androstenedione isn’t without risks. Liver stress, altered cholesterol levels, and potential heart issues have been reported, especially at high doses or with long‑term use. Women may experience deeper voice or increased facial hair if they take too much.

If you have a history of hormone‑sensitive cancers, liver disease, or are pregnant/breastfeeding, skip it entirely. Always talk to a healthcare professional before starting any supplement that meddles with hormones.

Legal Status and Buying Safely Online

In many countries, androstenedione is banned in sports and classified as a prescription‑only drug. In the U.S., it’s not approved for sale as a dietary supplement, which means you’ll often see it labeled under “research chemicals.” That makes buying online a bit tricky.

The safest route is to use a reputable pharmacy that follows strict verification processes. Look for sites that require a prescription or at least provide lab test results for purity. Avoid sellers with no clear contact info, vague product descriptions, or prices that seem too good to be true.

Bottom Line: Use Cautiously and Stay Informed

Androstenedione can give a modest bump in testosterone, but it’s not a magic bullet for muscle gain. Weigh the potential benefits against side effects like liver strain or hormonal imbalance. If you decide to try it, start low, monitor your body closely, and choose a trusted source.

Remember, the best way to boost strength and health is still solid training, balanced nutrition, and proper rest. Supplements can help, but they’re only one piece of the puzzle.